Enabling children and young people with epilepsy and related conditions to thrive and reach their ambitions
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Prognosis in Landau-Kleffner Syndrome (ELMO study)

Prognosis in Landau-Kleffner Syndrome and continuous spikes in slow-wave sleep syndromes - epileptic Encephalopathy Longitudinal Multicentre Omics study (ELMO).

Project aim

This is an international longitudinal, prospective multicentre cohort study which seeks to primarily determine if laboratory markers improve upon clinical prediction of disease course and response to treatment in children with difficult to treat epilepsy. Secondarily, the project will evaluate longitudinal changes in gene expression and gene methylation status that occur during the course of of epilepsy from the time of diagnosis

What this means

Epilepsies that seriously affect someone's normal development of cognition and behaviour and termed "epileptic encephalopathies" (EEs). However, the cause of 85% of cases remains unsolved. We want to better understand the effects these conditions have on the brain and to see if we can find a biomarker in the blood to better determine the cause of the problem in order to improve treatment and understanding of what to expect as the condition develops. We know this has been done for people with autism and Alzheimer's so we are hoping to use a similar approach with EE.


Their study has opened sites in the UK (London, Leeds, Edinburgh), France (Angers, Marseilles), Germany (Kiel) and Italy (Rome, Firenze, Milan) and is recruiting patients.


Deb Pal (Chief Investigator), Helen Cross (Local Principal Investigator).

Cyber EssentialsFundraising RegulatorYoung Epilepsy is the operating name of The National Centre for Young People with Epilepsy (NCYPE).
Registered Charity number 311877 (England and Wales)

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