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Non-invasive modulation of brain network dynamics

Non-invasive modulation of brain network dynamics to suppress epileptic activity and improve cognition (EPICONN TM)


A pilot study to measure a reduction in epileptiform activity associated with transcranial alternating current stimulation (tACS) and attention. We look to measure changes in brain connectivity and understand their relationship to epileptiform activity reduction. We hypothesise that in epilepsy brain networks can be targeted by weak electric fields applied to the scalp (tACS) to modulate the brain's connectivity to minimise epileptic activity and maximise cognitive performance.

What this means

We want to know mroe about how non-invasive electrical stimulation of the brain affects the brain and how this may be used to control seizures. We know surgery is not always successful and now everyone responds to antiepileptic drugs (AEDs). This project looks at a pioneering, and cost-effective, new treatment as an addition or alternative to surgery/AEDs.


This project has approval from the GOSH Clinical Research Adoptions Committee and an ethics application is underway with a view to open the study as soon as possible.


David Carmichael, Frederike Moeller, Elhum Shamshiri, Helen Cross

Cyber EssentialsFundraising RegulatorYoung Epilepsy is the operating name of The National Centre for Young People with Epilepsy (NCYPE).
Registered Charity number 311877 (England and Wales)

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