In this report, you can find a detailed summary of the 45 ongoing projects from within our research programme in 2022-2023.
The projects are presented under the workstream they most contribute to. They have coloured, numbered icons in the top right corner which illustrate all of the goals to which they contribute. Each project also features a purple ‘what this means?’ section which gives a summary of the work and intended impact.
Our research programme exists to ensure the best outcome for every child by optimising diagnosis, treatment and support for all aspects of childhood epilepsy.
Workstream 1: Understanding Childhood Epilepsies
- Gene-STEPS Project
We’re accelerating genetic diagnosis for infants with epilepsy under 12 months. Rapid whole genome sequencing has already led to diagnoses in 43% of cases, improving treatment and prognosis. - SCN1A Mutation Study
We’re investigating how different mutations in the same gene cause varied epilepsy symptoms. This helps us tailor treatments to individual genetic profiles. - Modelling Epilepsy in Zebrafish
Using transparent zebrafish larvae, we can observe brain activity at single-cell resolution, offering insights into severe childhood epilepsies and guiding future therapies.
Workstream 2: Outstanding Treatments
- MELD Project
We’ve built the largest neuroimaging dataset of focal cortical dysplasias (FCDs) and developed AI tools to detect lesions and predict surgical outcomes. These tools are now openly available to hospitals worldwide. - 7T MRI and EEG-fMRI Innovations
We’re pioneering ultra-high-resolution imaging to better detect subtle brain abnormalities. Our motion-corrected EEG-fMRI system improves accuracy, especially for children who struggle to stay still. - CADET Pilot (Deep Brain Stimulation)
We’ve launched a clinical trial to test DBS in children with Lennox-Gastaut Syndrome, aiming to reduce seizures and improve quality of life.
Workstream 3: Outstanding Support
- Epilepsy in Schools
We’re developing web-based training for teachers to improve understanding and support for children with epilepsy in mainstream education. - PACE Study
Our research shows children with epilepsy are less physically active. We’re now co-developing interventions to reduce barriers and promote exercise. - MICE Project
We’ve trialled routine mental health screening and telephone-based interventions in paediatric neurology clinics, helping children access psychological support.
