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Evaluating dietary intervention before surgical treatment

Evaluating dietary intervention before surgical treatment for epilepsy (EDIBLE)

Project aim

This is a work package of the European Union FP7 funded project DESIRE (Development and epilepsy - strategies for innovative research to improve diagnosis, prevention and treatment in children with difficult to treat epilepsy).

The work package is a randomised controlled trial to determine whether seizure freedom, in the treatment of epilepsy associated with focal cortical dysplasia type II, is more likely when resective surgery is performed after a ketogenic diet.

What this means

We are working with research teams across Europe to identify whether surgery is more likely to result in seizure freedom if patients with focal cortical dysplasia type II are on the ketogenic diet before surgery. If so, then we will look at creating new guidelines for pre-surgical treatment in order to increase the chances of seizure freedom after surgery for patients with this type of epilepsy.


Progress with this project has been extremely slow, not least due to the differing contractual and ethical requirements across site in different countries in Europe. Unfortunately, due to the poor recruitment and lack of remaining time, the study closed to recruitment in July 2017. A continued study of neuropathology aims to achieve the secondary aims of the study; for instance, whether ketogenic diet leads to methylation changes in tissue.


Helen Cross is the leader of this work package in the UK and Chief Investigator of the randomised controlled trial. It is coordinated through the Clinical Trials Unit at Liverpool University by the Research Coordinator, Christiana Papamichael.

Read more about other research projects

Cyber EssentialsFundraising RegulatorYoung Epilepsy is the operating name of The National Centre for Young People with Epilepsy (NCYPE).
Registered Charity number 311877 (England and Wales)

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