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Corticosteroids or clobazam for ESES Syndrome

Corticosteroids or clobazam for ESES Syndrome: a European, multicentre, randomised, controlled clinical trial (RESCUE ESES)


An international multicentre randomised controlled clinical trial with blinded outcome assessment to determine the best treatment for children with Electrical Status Epilepticus in Sleep (ESES) Syndrome.

What this means

Encephalopathy with Electrical Status Epilepticus in Sleep (ESES) Syndrome is a rare epilepsy syndrome of childhood that is characterised by epileptic activity during sleep and problems with cognition or behaviour. ESES resolves spontaneously in puberty, but cognitive problems often remain. Adequate treatment is mandatory to prevent or reverse these cognitive deficits. However, it is unknown which treatment is the best. Treatment with "standard" antiepileptic drugs is not very effective. Some studies suggest that clobazam and steroid treatment may be the best option. The only way to prove which treatment is best is to let a lottery decide which treatment a child gets (randomisation) and then compare the effects of both treatments.


This condition is incredibly rare and so recruitment is very slow but steady. We have opened at three UK sites (London, Edinburgh, Glasgow), and other European Union countries including Italy (Pavia), France (Paris, Lyon, Strasbourg), Belgium (Brussels, Leuven), Germany (Kehl, Freiburg, Kiel, Vogtareuth), Denmark (Dianalund), Finland (Helsinki), Romania (Bucharest), Bulgaria (Sofia) and Spain (Madrid).


Floor Jansen, Utrecht (Chief Investigator), Helen Cross (Local Principal Investigator)

Cyber EssentialsFundraising RegulatorYoung Epilepsy is the operating name of The National Centre for Young People with Epilepsy (NCYPE).
Registered Charity number 311877 (England and Wales)

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