Better futures for young lives with epilepsy and associated conditions

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Ketogenic diet in Infants with Epilepsy (KIWE)

The incidence of epilepsy is greatest in the first two years of life. Early control of seizures is associated with better developmental outcome but unfortunately many of the epilepsies presenting in infancy are associated with a poor prognosis for seizure control. There is limited data available with regard to effective treatments.

Aim

This is a randomised controlled trial to determine the effectiveness on seizure control of the ketogenic diet compared to alternative further antiepileptic drug treatment. Patients are children with epilepsy aged three months to two years who have failed to respond to two or more pharmacological treatments.

What this means

We want to know if the ketogenic diet is an effective treatment for epilepsy in infants who have not responded to twoor more antiepileptic drugs. We want to know if it is an effective alternative to trying additional antiepileptic drugs. we know the ketogenic diet works well for some older children but no-one has determined systematically if it works for infants. If it does, then it provides further options for early treatment.

Update

The project is currently recruiting at 12 centres across the UK. We aim to complete the recruitment by Janurary 2019. There have been numerous barriers to recruitment, but have achieved 50 recruited patients to date, one third of the way to our target. With the addition of four extra centres, we hope that recruitment will continue to be maintained.

Investigators

Christin Eltze, Colin Ferrie, Nicholas Freemantle, Simon Heales, Rachel Kneen, Louise Marston, Tim Martland, Helen McCullagh, Irwin Nazareth, Alasdair Parker, Ruth Williams, Helen Cross, Shakti Agrawal, Archana Desurkar, Anita Devlin, Helen Basu, Penny Fallon, Andrew Mallick, Andrew Lux, Rajib Samanta, Siobhan Titre-Johnson, Natasha Schoeler.

Cyber EssentialsFundraising RegulatorYoung Epilepsy is the operating name of The National Centre for Young People with Epilepsy (NCYPE).
Registered Charity number 311877 (England and Wales)

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