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Detect and delineate Focal Cortical Dysplasia (FCD)

Using new quantitative MRI tissue parameter maps to detect and delineate Focal Cortical Dysplasia (FCD).

Project aim

To develop better imaging methodology by investigating whether using quantitative analysis can provide improved detection, delieation and classification of FCD lesions. This is the first application of these scanning and analysis methods of epilepsy and may lead to a change in local, national and international practice in imaging childhood epilepsy.

What this means

We know that in FCD, lesions in the brain cause epilepsy. We are developing more accurate techniques for mapping these lesions using Magnetic Resonance Imaging (MRI) in order to greatly improve surgical planning and accuracy. We hope this will lead to better outcomes for children with FCD who have surgery and for us to be able to offer surgery to more children because we can map their lesions.


The team has published a recent review and been busy collating patient and control data including our motion correction technology. Sara Lorio has been working on improving the proton density maps that we obtain and processing susceptibility and diffusion maps with help from our collaborators. These are now starting to be assessed radiologically.


Sara Lorio, David Carmichael, Helen Cross, Nikolaus Weiskopf, Karin Shmueli, Thomas Jacques, Chris Clark, Kling Chong, Torsten Baldeweg.

Cyber EssentialsFundraising RegulatorYoung Epilepsy is the operating name of The National Centre for Young People with Epilepsy (NCYPE).
Registered Charity number 311877 (England and Wales)

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